Using a good web host is the most important security tip to keep in mind when you decide to create a web site.
Use a reliable web host with a good track record of support. Make sure you use a host that keeps their servers as secure as possible and the basic server scripts (PHP, MySQL, [...]

What You Need to Run The Mambo Open Source Content Management System
The minimum system requirements for running Mambo on your server space are:
Apache
The operating system Apache is installed on can be anything that the Apache platform supports, but it is Linux, Mac OS X, Windows 2000/XP and BSD that has been tested properly with Mambo. [...]